Melanoma is the most serious form of skin cancer. In many cases it can be fatal if left undiagnosed and allowed to metastasize to other parts of the body. One way to determine the full extent of a mark or mole on the skin is to have a melanoma biopsy. Usually, the mark will have been examined by a skin cancer professional who will suspect that it could be a melanoma. By having a biopsy, more information can be gained on the mark and confirm the diagnosis. It may also help determine any possible treatments for the disease.